ISR 4321 / 4331 EOL Replacement Comparison & Buying Guide

Cisco’s Integrated Services Router (ISR) 4000 Series has reached its End of Life (EoL) and End of Support (EoS) milestones, prompting many enterprises to plan their next-generation WAN and SD-WAN strategies. The logical successor is the Cisco Catalyst 8000 Series (C8200, C8300, C8500, and C8500L) — built on a modern IOS XE architecture and a unified DNA licensing framework.

Migrating from ISR4000 to Cat8000

This article explains why ISR4000 is being retired, how Catalyst 8000 replaces it, and what to consider when migrating, especially around DNA licensing and bandwidth tiers.

Cisco ISR4000 EoL and EoS Overview: Key Dates and Impact

Cisco has announced End-of-Life (EoL) and End-of-Support (EoS) dates for the ISR 4000 family, including:

Model

End of Sale

End of SW Maintenance

End of Support (EoS)

ISR 4221

Aug 2024

Aug 2026

Aug 2029

ISR 4321 / 4331

Jul 2024

Jul 2026

Jul 2029

ISR 4351 / 4431 / 4451

Jul 2024

Jul 2026

Jul 2029

While existing routers will continue to function, Cisco has ceased new feature development and stopped offering hardware refreshes. The Catalyst 8000 family is now the strategic replacement for all ISR 4000 deployments.

In short: ISR4000 is stable but frozen. Catalyst 8000 is the platform that will continue evolving under Cisco’s DNA architecture.

Why You Should Replace Cisco ISR4000 with Catalyst 8000 Routers

The move is not just a lifecycle refresh — it’s a foundation shift for the next decade of WAN connectivity.

Key reasons to upgrade:

  • Lifecycle: ISR 4000 is in EoL/EoS phase — no future updates or hardware refresh options.
  • Performance: C8000 delivers 2–5× higher IMIX throughput, up to 90Gbps aggregate, and supports modern encryption (AES-GCM).
  • Licensing: Simplified DNA subscription model (Network Stack + DNA Stack) replaces the legacy perpetual SKU maze.
  • Security & SD-WAN: Native Cisco SD-WAN (vManage) and Zero-Trust segmentation.
  • Investment Protection: DNA licenses can migrate from ISR/ASR to C8000 under Cisco’s Smart Licensing system.

Model Replacement Chart: ISR4221, ISR4331, ISR4451 → C8200, C8300, C8500

Performance Comparison and Feature Parity

Below is a field-tested migration mapping based on performance equivalence and feature parity.

migrate ISR 4000 to catalyst 8000

Legacy ISR 4000

Typical Performance

Recommended Replacement

New Performance

Recommended DNA Tier

ISR 4221

~1.2 Gbps / 250 Mbps encrypted

C8200-1N-4T or C8200L-1N-4T

~3.8 Gbps / 0.5–1 Gbps

DNA Essentials (T0–T1)

ISR 4321

~1.6 Gbps / 325 Mbps encrypted

C8200-1N-4T

~3.8 Gbps / ~1 Gbps

DNA Advantage (T1)

ISR 4331

~1.8 Gbps / 500 Mbps encrypted

C8300-1N1S-6T

~10 Gbps / ~2 Gbps

DNA Advantage (T2)

ISR 4351

~3.4 Gbps / 900 Mbps encrypted

C8300-2N2S-6T

~10 Gbps / ~2 Gbps

DNA Advantage (T2)

ISR 4431 / 4451

~3.8 Gbps / 1.6 Gbps encrypted

C8300-2N2S-4T2X

~12 Gbps / 5 Gbps

DNA Advantage (T2–T3)

Choosing the Right Model Based on Site Size

If your ISR 4000 was already running near its maximum utilization, choose a Catalyst 8000 model two tiers higher to ensure headroom for future SD-WAN, telemetry, or cloud security services.

Cisco ISR4400 vs C8300 Product Comparison

Specification

C8300-2N2S-4T2X

ISR4451

C8300-1N1S-6T

ISR4431

IPsec Tunnels

6000

4000

6000

3500

SD-WAN IPsec

5 Gbps

1 / 1.4 Gbps (**)

1.8 Gbps

490 / 750 Mbps (**)

CEF (Routing)

12+ Gbps

1 / 3.8 Gbps (**)

10+ Gbps

0.5 / 3.4 Gbps (**)

Non-SD-WAN IPsec

5 Gbps

1 / 1.8 Gbps (**)

1.9 Gbps

0.5 / 1 Gbps (**)

DRAM

Default 8 GB / Up to 32 GB

Default 4 GB / Up to 16 GB

Default 8 GB / Up to 32 GB

Default 4 GB / Up to 16 GB

Embedded Ports / Modularity

4 × RJ45 + 2 × SFP+ / 2 × NIM + 2 × SM + 1 × PIM

4 × RJ45/SFP / 3 × NIM + 2 × SM

4 × RJ45 + 2 × SFP+ / 1 × NIM + 1 × SM + 1 × PIM

4 × RJ45/SFP / 3 × NIM

Cisco ISR4300 vs C8200 Product Comparison

Specification

C8200-1N-4T

ISR4331

C8200L-1N-4T

ISR4321

IPsec Tunnels

2500 (SD-WAN)

1000 (SD-WAN)

1500 (SD-WAN)

250 (SD-WAN)

SD-WAN Performance

1 Gbps

100 Mbps* / 485 Mbps**

500 Mbps

50 Mbps* / 300 Mbps**

CEF (Routing)

3.8 Gbps

100 Mbps* / 1.8 Gbps**

3.8 Gbps

50 Mbps* / 1.6 Gbps**

IPSec (Non-SD-WAN)

1 Gbps

100 Mbps* / 445 Mbps**

500 Mbps

50 Mbps* / 300 Mbps**

DRAM

Default 8 GB / Up to 32 GB

Default 4 GB / Up to 16 GB

Default 4 GB / Up to 32 GB

Default 4 GB / Up to 8 GB

Embedded Ports / Modularity

2 × RJ45 + 2 × SFP / 1 × NIM + 1 × PIM

2 × RJ45 + 1 × RJ45/SFP / 2 × NIM + 1 × SM

2 × RJ45 + 2 × SFP / 1 × NIM + 1 × PIM

1 × RJ45 + 1 × RJ45/SFP / 2 × NIM

Understanding Cisco DNA Licensing for Catalyst 8000 Migration

Network Stack (Perpetual License)

Provides baseline routing (IOS XE, DMVPN, GETVPN, FlexVPN, etc.) and never expires — routing continues even after DNA subscription ends.

DNA Stack (Subscription License and Terms)

Time-limited (3/5/7 years) and enables SD-WAN control, DNA Center automation, and analytics. Required for controller mode.

DNA Essentials vs DNA Advantage Explained

License Type

Duration

Controller Support

Renewal Needed

Best For

DNA Essentials

3Y/5Y

Limited

Optional

Traditional routing

DNA Advantage

3Y/5Y/7Y

Full (vManage/DNAC)

Required

SD-WAN & analytics

Step-by-Step Migration Plan from ISR4000 to Catalyst 8000

1. Assessment and Planning Phase

  • Inventory ISR hardware, throughput, and VPN utilization
  • Gather license entitlements from Smart Account
  • Estimate future encrypted traffic growth

2. Design and Licensing Phase

  • Map each ISR to Catalyst 8000 equivalent
  • Choose DNA subscription (3/5/7Y) and BW tier
  • Plan for HSEC activation

3. Implementation and Rollout

  • Pilot with one site under Autonomous Mode
  • Validate routing, QoS, NAT, and SD-WAN template behavior
  • Migrate site by site with rollback configuration retained

Related Reading: DNA Licensing, Bandwidth Tiers, and SD-WAN Migration

FAQ

Q1. What does Cisco ISR4000 EoL mean for existing users?

Cisco has announced End-of-Life (EoL) and End-of-Support (EoS) for ISR4000 routers, meaning no new software updates or hardware refresh options will be provided. Users should plan migration to the Catalyst 8000 series.

Q2. Which Catalyst 8000 model replaces Cisco ISR4331 or ISR4351?

Cisco recommends the Catalyst C8300-1N1S-6T or C8300-2N2S-6T as direct replacements for ISR4331 and ISR4351, offering higher throughput, SD-WAN support, and flexible DNA licensing.

Q3. Can I reuse my ISR4000 DNA license when moving to Catalyst 8000?

Yes. Cisco Smart Licensing supports DNA license migration from ISR4000 or ASR1000 to Catalyst 8000 routers, preserving existing entitlements and subscription terms.

Q4. What is the difference between DNA Essentials and DNA Advantage?

DNA Essentials provides standard routing and automation, while DNA Advantage includes SD-WAN, segmentation, and advanced analytics. For controller-managed networks, DNA Advantage is required.

Q5. Do I need the HSEC license after replacing my ISR router?

If your encrypted (IPsec or SD-WAN) traffic exceeds 250 Mbps, an HSEC license is required on Catalyst 8000 routers to unlock full encryption throughput and remain compliant.

Q6. Will my network stop working if the DNA subscription expires?

No. The Network Stack license on Catalyst 8000 is perpetual, so routing continues even after DNA subscription expiry. However, controller functions (vManage, DNA Center) will be disabled until renewal.

End-of-Life (EoL) Checker

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