ISR4221/K9 – 2×GE WAN/LAN Ports – 2×NIM Slots – ISR 4221 Router

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ISR4221/K9 Description

Cisco ISR4221/K9, also called ISR 4221 or Cisco 4221 router, is the entry-level model in the Cisco 4000 Series Integrated Services Routers. Designed for small offices and remote branches, it provides two Gigabit Ethernet ports (one RJ-45 and one SFP), two NIM slots for WAN or voice modules, and license-based throughput scalability from 35 Mbps to 75 Mbps. The router has fixed DRAM (4 GB or 8 GB for ISR4221X) and flash memory, with no SM-X or on-board PVDM slots. While it does not support PoE, it maintains modularity with WAN, xDSL, LTE, and serial NIMs, making it a cost-effective and secure solution for entry-level branch connectivity.

Product Highlights

Aggregate Throughput (Default)
RJ-45-based ports
SFP-based ports

Front View

1

Grounding

2

Power input connector

3

Power switch

4

USB

5

Console port

6

GE 0/0/0 RJ-45 (copper cable) port

7

GE 0/0/0 SFP (fiber-optic) port

8

GE 0/0/1 (copper cable) port

Quick Specs

Parameter

Specification

GE Ports

2 × 10/100/1000 (1 × RJ-45, 1 × SFP)

NIM Slots

2

SM-X Slot

None

On-board PVDM/ISC

None

Aggregate Throughput

35–75 Mbps (licensed)

Default / Max DRAM

4 GB / 4 GB (4221), 8 GB fixed (4221X)

Default / Max Flash

8 GB / 8 GB

Power with PoE

Not supported (no PoE PSU option)

Rack Units

1 RU

Weight

~3.2–3.7 kg (depending on PSU type)

Key Features

Entry-Level Branch Routing with Flexible Performance

ISR4221/K9 provides 35–75 Mbps throughput under license, offering an affordable starting point for small offices and scaling as bandwidth needs increase.

Compact Modular Design

With 2 NIM slots, the router supports WAN diversity such as LTE, xDSL, serial, and PRI/BRI, allowing branches to adapt to changing access requirements.

Voice and Collaboration Support via Modules

Compatible with voice NIMs that include onboard PVDM4 DSPs, enabling SRST, transcoding, and conferencing to keep local telephony operational during WAN outages.

Secure WAN Edge for Small Sites

Integrated IOS XE security features, VPN encryption, and SD-WAN readiness make the ISR4221 suitable for distributed enterprises with compliance-driven connectivity needs.

Low Power and Silent Efficiency

Lightweight 1RU form factor, low acoustic profile, and efficient energy use make it ideal for constrained retail or office environments where space and noise matter.

Simple Deployment and Remote Management

Zero-touch provisioning, centralized management with Cisco Catalyst Center, and compatibility with Cisco DNA licensing simplify operations for lean IT teams.

Application Scenarios

Retail Stores and Franchise Branches

Provides secure VPN connectivity for POS transactions, supports LTE backup modules for continuity, and offers optional EtherSwitch NIMs for powering limited branch devices.

Healthcare Clinics and Banking Kiosks

Delivers reliable WAN connectivity with encrypted tunnels, while supporting local SRST voice through voice NIMs to maintain communication during outages.

Government and Education Edge Sites

Affordable and compact, ISR4221 is ideal for small agencies, schools, or local offices that require modular WAN expansion, secure hybrid WAN, and easy-to-manage routing at the edge.

Product Comparison

Feature

ISR4221/K9

ISR4321/K9

ISR4331/K9

GE Ports

2 (1 RJ-45, 1 SFP)

2 (RJ-45/SFP combo)

3 (2 combo + 1 RJ-45)

NIM Slots

2

2

2

SM-X Slot

None

None

1

On-board PVDM/ISC

None

None (voice via NIMs)

1

DRAM Default / Max

4 / 4 GB (8 GB fixed on 4221X)

4 / 8 GB

4 / 16 GB

Flash Default / Max

8 / 8 GB

4 / 8 GB

4 / 16 GB

Aggregate Throughput

35–75 Mbps

50–100 Mbps

100–300 Mbps

PoE Budget Max

Not supported

125 W (via EtherSwitch NIM)

250 W

Rack Units

1 RU

1 RU

1 RU

Weight

~3.2–3.7 kg

~4.8 kg

~5.6 kg

ISR4221/K9 Supported Modules

Module Type / Part Numbers

Supported on ISR4221/K9

Network Interface Modules (NIMs)

Yes – 2 slots (single-wide or one double-wide with divider)

NIM-1GE-CU-SFP / NIM-2GE-CU-SFP

Yes

NIM-1MFT-T1/E1 / NIM-2MFT-T1/E1

Yes

NIM-4MFT-T1/E1 / NIM-8MFT-T1/E1

Yes

NIM-1CE1T1-PRI / NIM-2CE1T1-PRI

Yes

NIM-ES2-8 / NIM-ES2-8-P

Yes (no PoE output on ISR4221)

NIM-SSD / NIM-HDD

Yes

NIM LTE / xDSL variants

Yes (regional SKUs apply)

Service Modules (SM-X)

Not supported

On-board PVDM4

Not supported (voice via NIM DSPs)

SFP Modules

Supported (100M/1G SFP)

Legacy WIC/EHWIC

Not supported

Specifications

Parameter Specification Parameter Specification
Model ISR4221 (Cisco 4000 Series ISR) Form Factor 1RU rack-mount
GE Ports 2 (1 RJ-45, 1 SFP) NIM Slots 2
SM-X Slot None On-board PVDM/ISC Not present (voice DSP via NIMs)
DRAM 4 GB fixed (4221), 8 GB fixed (4221X) Flash 8 GB fixed
Aggregate Throughput 35–75 Mbps (licensed) Encryption Hardware-assisted VPN
USB Ports USB 2.0 Type-A, mini-USB console Console / AUX RJ-45 console, RJ-45 auxiliary
Operating System Cisco IOS XE Power Supply External AC PSU only
PoE Capability Not supported Cooling Integrated fan system
Operating Temp 0–40 °C Humidity 5%–85% non-condensing
Dimensions (H×W×D) 1.72 × 12.7 × 10 in (43.7 × 322.6 × 254 mm) Weight ~3.2–3.7 kg
Compliance IEC/EN/UL 60950-1/62368-1, CISPR 22/24 Class A Licensing Performance, Security, UC, AppX

Get More Information

Need pricing, stock, or shipping details for the ISR4221/K9 ? Layer23-Switch can help you check current availability, lead time, and delivery options for this. Send us the part number, quantity, and destination country via live chat or email sales@layer23-switch.com for a fast quotation.

Quality Certifications

Customer Reviews

Write A Review
4.7
(6 reviews)
5 Stars
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2
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0
2 Stars
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1 Stars
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    Andrea Sanders
    Posted on 30/04/2026
    Verified Buyer
    4.0

    Quality of every unit was uniform. No variation across the order. Wish the lead time was a bit shorter, but product quality made up for it.

    Justin Graham
    Posted on 09/01/2026
    Verified Buyer
    4.0

    Working with Layer23 is what every vendor relationship should feel like.

    Sophia Tucker
    Posted on 05/01/2026
    Verified Buyer
    5.0

    Our procurement team was impressed that the pricing came in under our estimate.

    C-3PO
    Posted on 30/08/2024
    Verified Buyer
    5.0

    The odds of this router failing are 3,720 to 1. It is functioning perfectly.

    Retail Tech
    Posted on 20/04/2024
    Verified Buyer
    5.0

    Very basic, very reliable. Perfect for simple MPLS endpoints.

Questions & Answers

  • What is ISR4221/K9 used for?

    ISR4221/K9 is the low-end Cisco 4000 Series branch router for small WAN edge, VPN, and SD-WAN routing needs.
  • What throughput can ISR4221/K9 provide?

    ISR4221/K9 provides 35 Mbps aggregate throughput by default and reaches 75 Mbps with the performance license.
  • How many onboard Gigabit Ethernet ports does ISR4221/K9 have?

    ISR4221/K9 has two onboard Gigabit Ethernet ports, matching its small-branch routing role and low-throughput 35/75 Mbps positioning.
  • What module slots are on ISR4221/K9?

    ISR4221/K9 has 2 NIM slots and 1 ISC slot, giving entry-level module expansion without service-module capacity.
  • How is ISR4221/K9 different from ISR4221X/K9?

    ISR4221/K9 has 4 GB DRAM default, while ISR4221X/K9 raises default DRAM to 8 GB on the same 4221 family.
  • How is ISR4221/K9 different from ISR4321/K9?

    ISR4221/K9 is the 35 Mbps default and 75 Mbps licensed tier, while ISR4321/K9 is the 50 Mbps default and 100 Mbps licensed tier.
  • Can ISR4221/K9 use performance licensing?

    Yes. ISR4221/K9 can move from 35 Mbps to 75 Mbps aggregate throughput with the ISR 4220 performance-license path.
  • What memory and flash are listed for ISR4221/K9?

    ISR4221/K9 is listed with 4 GB DRAM default and 8 GB flash default, separating it from the 4 GB flash 4321 model.

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DataSheet Downloads

  • ISR4221-K9 Datasheet