ISR4221/K9 – router – rack-mountable

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ISR4221/K9

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List Price: $3827 $517
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Weight 3.8 kg
Dimensions 34 × 12 × 47 cm
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ISR4221/K9 Description

Cisco ISR4221/K9, also called ISR 4221 or Cisco 4221 router, is the entry-level model in the Cisco 4000 Series Integrated Services Routers. Designed for small offices and remote branches, it provides two Gigabit Ethernet ports (one RJ-45 and one SFP), two NIM slots for WAN or voice modules, and license-based throughput scalability from 35 Mbps to 75 Mbps. The router has fixed DRAM (4 GB or 8 GB for ISR4221X) and flash memory, with no SM-X or on-board PVDM slots. While it does not support PoE, it maintains modularity with WAN, xDSL, LTE, and serial NIMs, making it a cost-effective and secure solution for entry-level branch connectivity.

Product Highlights

Aggregate Throughput (Default)
RJ-45-based ports
SFP-based ports

Front View

ISR4221/K9

1

Grounding

2

Power input connector

3

Power switch

4

USB

5

Console port

6

GE 0/0/0 RJ-45 (copper cable) port

7

GE 0/0/0 SFP (fiber-optic) port

8

GE 0/0/1 (copper cable) port

Quick Specs

Parameter

Specification

GE Ports

2 × 10/100/1000 (1 × RJ-45, 1 × SFP)

NIM Slots

2

SM-X Slot

None

On-board PVDM/ISC

None

Aggregate Throughput

35–75 Mbps (licensed)

Default / Max DRAM

4 GB / 4 GB (4221), 8 GB fixed (4221X)

Default / Max Flash

8 GB / 8 GB

Power with PoE

Not supported (no PoE PSU option)

Rack Units

1 RU

Weight

~3.2–3.7 kg (depending on PSU type)

Key Features

Entry-Level Branch Routing with Flexible Performance

ISR4221/K9 provides 35–75 Mbps throughput under license, offering an affordable starting point for small offices and scaling as bandwidth needs increase.

Compact Modular Design

With 2 NIM slots, the router supports WAN diversity such as LTE, xDSL, serial, and PRI/BRI, allowing branches to adapt to changing access requirements.

Voice and Collaboration Support via Modules

Compatible with voice NIMs that include onboard PVDM4 DSPs, enabling SRST, transcoding, and conferencing to keep local telephony operational during WAN outages.

Secure WAN Edge for Small Sites

Integrated IOS XE security features, VPN encryption, and SD-WAN readiness make the ISR4221 suitable for distributed enterprises with compliance-driven connectivity needs.

Low Power and Silent Efficiency

Lightweight 1RU form factor, low acoustic profile, and efficient energy use make it ideal for constrained retail or office environments where space and noise matter.

Simple Deployment and Remote Management

Zero-touch provisioning, centralized management with Cisco Catalyst Center, and compatibility with Cisco DNA licensing simplify operations for lean IT teams.

Applications Scenarios

Retail Stores and Franchise Branches

Provides secure VPN connectivity for POS transactions, supports LTE backup modules for continuity, and offers optional EtherSwitch NIMs for powering limited branch devices.

Healthcare Clinics and Banking Kiosks

Delivers reliable WAN connectivity with encrypted tunnels, while supporting local SRST voice through voice NIMs to maintain communication during outages.

Government and Education Edge Sites

Affordable and compact, ISR4221 is ideal for small agencies, schools, or local offices that require modular WAN expansion, secure hybrid WAN, and easy-to-manage routing at the edge.

Product Comparison

Feature

ISR4221/K9

ISR4321/K9

ISR4331/K9

GE Ports

2 (1 RJ-45, 1 SFP)

2 (RJ-45/SFP combo)

3 (2 combo + 1 RJ-45)

NIM Slots

2

2

2

SM-X Slot

None

None

1

On-board PVDM/ISC

None

None (voice via NIMs)

1

DRAM Default / Max

4 / 4 GB (8 GB fixed on 4221X)

4 / 8 GB

4 / 16 GB

Flash Default / Max

8 / 8 GB

4 / 8 GB

4 / 16 GB

Aggregate Throughput

35–75 Mbps

50–100 Mbps

100–300 Mbps

PoE Budget Max

Not supported

125 W (via EtherSwitch NIM)

250 W

Rack Units

1 RU

1 RU

1 RU

Weight

~3.2–3.7 kg

~4.8 kg

~5.6 kg

ISR4221/K9 Supported Modules

Module Type / Part Numbers

Supported on ISR4221/K9

Network Interface Modules (NIMs)

Yes – 2 slots (single-wide or one double-wide with divider)

NIM-1GE-CU-SFP / NIM-2GE-CU-SFP

Yes

NIM-1MFT-T1/E1 / NIM-2MFT-T1/E1

Yes

NIM-4MFT-T1/E1 / NIM-8MFT-T1/E1

Yes

NIM-1CE1T1-PRI / NIM-2CE1T1-PRI

Yes

NIM-ES2-8 / NIM-ES2-8-P

Yes (no PoE output on ISR4221)

NIM-SSD / NIM-HDD

Yes

NIM LTE / xDSL variants

Yes (regional SKUs apply)

Service Modules (SM-X)

Not supported

On-board PVDM4

Not supported (voice via NIM DSPs)

SFP Modules

Supported (100M/1G SFP)

Legacy WIC/EHWIC

Not supported

Specifications

Parameter Specification Parameter Specification
Model ISR4221 (Cisco 4000 Series ISR) Form Factor 1RU rack-mount
GE Ports 2 (1 RJ-45, 1 SFP) NIM Slots 2
SM-X Slot None On-board PVDM/ISC Not present (voice DSP via NIMs)
DRAM 4 GB fixed (4221), 8 GB fixed (4221X) Flash 8 GB fixed
Aggregate Throughput 35–75 Mbps (licensed) Encryption Hardware-assisted VPN
USB Ports USB 2.0 Type-A, mini-USB console Console / AUX RJ-45 console, RJ-45 auxiliary
Operating System Cisco IOS XE Power Supply External AC PSU only
PoE Capability Not supported Cooling Integrated fan system
Operating Temp 0–40 °C Humidity 5%–85% non-condensing
Dimensions (H×W×D) 1.72 × 12.7 × 10 in (43.7 × 322.6 × 254 mm) Weight ~3.2–3.7 kg
Compliance IEC/EN/UL 60950-1/62368-1, CISPR 22/24 Class A Licensing Performance, Security, UC, AppX

Get More Information

Discover unbeatable prices and fast shipping for the ISR4221/K9 Access the detailed ISR4221/K9 datasheet and ensure you’re getting the best deal with our reliable delivery service. Need assistance? Our free live chat support is here to help. For more information about the product and pricing, contact us via Live chat or email us at [email protected]

Quality Certifications

Customer Reviews

Write A Review
5.0
(3 reviews)
5 Stars
3
4 Stars
0
3 Stars
0
2 Stars
0
1 Stars
0
    C-3PO
    Posted on 30/08/2024
    Verified Buyer
    5.0

    The odds of this router failing are 3,720 to 1. It is functioning perfectly.

    Retail Tech
    Posted on 20/04/2024
    Verified Buyer
    5.0

    Very basic, very reliable. Perfect for simple MPLS endpoints.

    Purchasing
    Posted on 05/01/2024
    Verified Buyer
    5.0

    Bulk buy of 20. Good discount.

Questions & Answers

  • What is ISR4221/K9 designed for?

    A cost-efficient ISR 4000 for very small branches or kiosks, delivering secure WAN, basic voice, and optional SD-WAN in a compact chassis.

  • How does ISR4221 compare to ISR4321?

    4221 targets the smallest sites with lower throughput. Move to 4321 if VPN, voice, or service scale increases.

  • Is SD-WAN available?

    Yes. It can be enrolled in Cisco SD-WAN for centralized policy and monitoring or run traditionally with IOS XE.

  • What voice features are typical?

    SRST for survivability, small CUBE session counts, and analog integration via voice NIMs as needed.

  • Resiliency considerations?

    Plan dual WAN or LTE fallback where uptime is critical. Validate failover for payment systems and voice.

  • Management and automation?

    Use the web UI initially; expand to APIs and templates for consistent rollouts. Enable telemetry for visibility.

  • Deployment examples?

    Kiosks, retail counters, small clinics, and micro-offices with limited devices.

  • Licensing tips?

    Keep licenses minimal and aligned to actual usage; scale up if traffic or voice needs grow.

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Resources Downloads

  • ISR4221-K9 Datasheet

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